Question

Between a 5 year-old child, a 15 year-old teenager, a 35 year-old man and a 75 year-old grandpa, who will experience the most, the toxic effects of a specific dose of a given substance and why? If your answer is more than one, please elaborate.

Answer 1

Between a 5 year-old child, a 15 year-old teenager, a 35 year-old man and a 75 year- old grandpa, who will experience the most, the toxic effects of a specific dose of a given substance and why? If your answer is more than one, please elaborate.

Answer:- Between a 5 year-old child and 75 year- old grandpa will experience the most, the toxic effects of a specific dose of a given substance.

Explanation- Due to decreased body size, altered body composition (more fat, less water), and decreased liver and kidney function along with high cholesterol, coronary artery disease, high blood pressure, type 2 diabetes, arthritis etc causes many drugs to accumulate in older people's bodies at a higher levels and for longer times than younger adults.
Where as younger children tend to absorb medicine more slowly from the stomach but have faster intramuscular absorption rates. Lower rate may be odue to the larger liver size. Liver enzymes are immature as well as their kidney function too. So young children seem to be less sensitive to acute intoxication than adults.