Question

1) Describe the viral structure of Zika. 2) What type of nucleic acid is in Zika? 3) Which virus family is Zika a part of? 4) How is Zika transmitted? 5) What are the symptoms of Zika in both general hosts and also pregnant women and the baby that they are carrying?

Answer 1

Zika virions are comprised of an envelope and a nucleocapsid. The virusparticles are spherical and small in size (approximately 50 nm in diameter) with an electron-dense core approximately 30 nm in diameter. The virion surface contains envelope protein (E) dimers and membrane (M) proteins in icosahedral-like symmetry.

→ Envelope (dimer) → Membrane protein Single-stranded, positive-sense RNA genome, unsegmented → Capsid protein Enveloped icosahedral capsid Genomic large polyprotein 5 Furin Cleavage by host and viral proteases prM C pr M NS1 NSZA NSB NS3 NSA NS4B NS5 Converts immature prm into mature pr and M For formation of the nucleocapsid Protects E V Envelope protein during Brycoprotein, target in during glycoprotein, target assembly for neutralizing antibodies Non structural proteins role in replication and also invoking cell-mediated immune response

2. - RNA genome (yellow) is associated with capsid proteins (orange).

3. - Zika virus (ZIKV) (pronounced /ˈziːkə/ or /ˈzɪkə/) is a member of the virus family Flaviviridae.

4. It is spread by daytime-active Aedes mosquitoes, such as A. aegypti and A. albopictus. ... Zika virus is related to the dengue, yellow fever, Japanese encephalitis, and West Nile viruses.

Pregnant women who have traveled to areas with known cases of Zika virus transmission Zika symptoms present during or within two weeks of travel No Zika symptoms present during or within two weeks of travel Test woman for Zika virus infection Do fetal ultrasound to detect microcephaly or skull calcifications Do fetal ultrasound or amniocentesis to test baby for Zika virus Do fetal ultrasound to detect microcephaly or skull calcifications Schedule regular ultrasounds to detect any development of microcephaly or skull calcifications Do amniocentesis to test baby for Zika virus HEALTH SCIENCE CENTER TEXAS A&M UNIVERSITY Source: CDC testing algorithm January 19, 2016 transforming HEALTH

Zika virus : Associated conditions Adult Fetus/Neonate Cardiovascular anomalies Myalgia Placenta Vertical transmission Arthralgia Optic neuropathy + Congenital glaucoma Maculopapular rash Guillain-Barré Syndrome .Microcephaly .Lissencephaly Ventriculomegaly

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