3)ANSWER Pyruvate convert in acetyl-CoA by the enzyme complex pyruvate dehydrogenase complex in the mitochondrial matrix.
4) answer - Lactate dehydrogenase(LDH) catalyzes the conversion of pyruvate to lactate known as cori cycle. this process occurs in skeletal muscle cells. Aside from pyruvate glyceraldehyde3-phosphate dehydrogenase and 1,3-bis phosphoglycerate require for the completion of cori cycle.
FIGURE 1 ! Figure 1. Lactate metabolism in tumors: a simplified cartoon showing lactate being shuttled...
based on this information , how does lactate influence angiogenisis in tumors ?? thank you in advance Figure 1. Lactate metabolism in tumors: a simplified cartoon showing lactate being shuttled to and from cancer cells and its potential role as a signaling molecule in driving angiogenesis. Increasing pyruvate inhibits formation of 2- oxoglutarate, with the net effect of less degradation of HIF-1a in the proteasome and increased VEGF and angiogenesis. Note that pyruvate can be increased by hypoxia "backing up"...
1. An important paper published by Granchi et al. summarizes therapeutic potential of lactate dehydrogenase inhibitors (Curr Med Chem. 2010;17(7):672-97). Part of the abstract from this paper is shown below: Abstract: "In many different species, lactate dehydrogenase (LDH) constitutes a major checkpoint of anaerobic glycolysis, by catalyzing the reduction of pyruvate into lactate. This enzyme has recently received a great deal of attention since it may constitute a valid therapeutic target for diseases so different as malaria and cancer. In...
1. According to the paper, what does lactate dehydrogenase (LDH) do and what does it allow to happen within the myofiber? (5 points) 2. According to the paper, what is the major disadvantage of relying on glycolysis during high-intensity exercise? (5 points) 3. Using Figure 1 in the paper, briefly describe the different sources of ATP production at 50% versus 90% AND explain whether you believe this depiction of ATP production applies to a Type IIX myofiber in a human....