Question

14. Huntington's Disease, an autosomal dominant disorder, was linked to a Hindill digestion site using a Southern Blot and a specific probe. Researchers detected four different digestion patterns, three of which are below (called haplotypes A, B, and C). Haplotype A is linked to the defective huntingtingene, which causes neurodegeneration. a. Which individuals (#1-7) have Huntington's Disease? b. Which band size on the gel represents haplotype B? C. A person has bands only at 3.7/1.2 kb (not 4.9 kb) but they don't have the disease. What is their genotype (e.g. A/A)? 15 tb - 4 Alleles -49 -37 123 Hind ISIN" Alleles Hind Sie 1 150 37 723

Answer 1

a. #1 , #2 , #6 will have Huntington's Disease.

Because the condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. An affected person usually inherits the altered gene from one affected parent.

b. 4.9 kb size on the gel represents haplotype B .

c. The genotype will be C / C .