Question

Based on your knowledge of complement activation pathways, predict which group of pathogens would be MOST susceptible to lysis by MACs.

Gram-negative pathogens

Enveloped viruses

Gram-positive pathogens

Gram-negative pathogens and enveloped viruses are equally susceptible.

Gram-negative pathogens and enveloped viruses are equally susceptible.

Every possible light chain that could be formed, in terms of receptor specificity, is encoded by a separate gene within the human genome.

Light chains are produced by means of somatic rearrangement of germ-line DNA in B cells.

The different light-chain variable regions are produced by means of alternative splicing of pre-mRNA that has been transcribed from a fixed, unchanging DNA sequence.

Different light chains, each with unique specificity, are produced via the activity of alternative transcription factors that regulate antibody production at the level of transcription initiation.

Answer 1

Answer
1. Gram-negative pathogens and enveloped viruses are equally susceptible.
The gram negative bacteria are attack by MAC complex more rapidly than Gram positive bacteria.

2. B. Light chains are produced by means of somatic rearrangement of germ-line DNA in B cells.