2) Drosophila muscleblind (Mbl) is an RNA binding protein necessary for early development of null flies...
2) Drosophila muscleblind (Mbl) is an RNA binding protein necessary for early development of null flies in the late embryo stages. The same class of proteins, the MBNL proteins, have been shown to play an important role in myotonic dystrophy in humans. During a study, various RNA sequences were added to Mbl to determine if common structural characteristics arose in structures that showed strong binding characteristics to the protein. Below are two RNA structures that showed strong bonding characteristics (12 pts). Structure A Structure B part B a) On structure A, identify hairpin loops on the structure by circling with a blue pen. (3pts) b) Below, draw the identified 2 nucleobase sequences on structure B with correct structural characteristics found on nucleobases. ribose structures, and Watson-Crick base pairs. Also include the nucleobases connected to the ends of the duplex, and 3'- and 5'. sides to the duplex. (9 pts)