Why all major drugs currently in clinical trials modulate protein phosphorylation – unfortunately, (<90%) will fail? What is attractive about ubiquitin ligases in comparison to kinases/phosphatases with respect to drug development?
The ubiquitin ligase helps in tagging of foreign particles or antigen with ubiquitinin. As ubiquitin is attached to a antigen , it is directed to proteasome complex which degrades it and transform it into peptide fragmments which then presented as outside the cell with MHC and induce antibody development. Similarly new drugs will be displayed with MHC which will act as vaccine and induce antibody development. These antibodies will protect body when real antigen will enter the body in due course of infection.
Why all major drugs currently in clinical trials modulate protein phosphorylation – unfortunately, (<90%) will fail?...
Please read the article bellow and discuss the shift in the company's approach to genetic analysis. Please also discuss what you think about personal genomic companies' approaches to research. Feel free to compare 23andMe's polices on research with another company's. Did you think the FDA was right in prohibiting 23andMe from providing health information? These are some sample talking points to get you thinking about the ethics of genetic research in the context of Big Data. You don't have to...
1. According to the paper, what does lactate dehydrogenase (LDH) do and what does it allow to happen within the myofiber? (5 points) 2. According to the paper, what is the major disadvantage of relying on glycolysis during high-intensity exercise? (5 points) 3. Using Figure 1 in the paper, briefly describe the different sources of ATP production at 50% versus 90% AND explain whether you believe this depiction of ATP production applies to a Type IIX myofiber in a human....