Question

Question 3 (1 point) Which of the following correctly describes how expression or function of MYC happens? (Don't worry about correct capitalization or type style in this question.) O A chromosomal translocation that puts an active promoter region for antibody genes in close proximity to the myc gene, leading to overproduction of MYC. The avian myelocytomatosis virus carries an altered version of myc (v-myc) that is hyperactive. The virus genome integrates into the host genome and the altered form of MYC is produced. Viral genome integration can occur near the normal cellular MYC gene. Viral LTRs then act as promoter regions to increase transcription of MYC. O All of the above are correct.

Answer 1

Answer 2) NF-Kappa B (1)helps in the expressions of genes involved in cellular proliferation as when NF-Kappa genes get activated,it further activates cell proliferation activity and prevents the cells from cancer (2) increases expression of genes that inhibits apoptosis;This cell proliferation activity keeps the genes active and leads to protection of cell and forbid/inhibits undergoing apoptosis (3) NF-Kappa B is activated by compounds released by macrophages in chronic inflammation, one of the major function of NF-Kappa B is to control many regulatory genes involved in inflammation as activation of NF-kappa B in different cell lineages or cell lines plays a tissue specific role in inflammation. The deletion of IKK beta and gamma that lies in intestine proves a cytoprotective role for NF-kaapa B (4) Yes all of the above options describes NF-Kappa B

Answer1)(i) Chromosomal translocation oocurs in humans and is targeted with coding sequence of c-myc genes and genes are quantitatively expressd thats leads to MYC overproduction (ii)Avian myelocytomatosis has similarity with Myc proteins and carries MC29 as an alternate version of v Myc and provides inhibition to oncoproteins (iii) viral genome activation can occur near normal myc genome, as LTR controls the expression of simple retroviruses as virus enhancers withn LTC increases transcription from the normal genome (4) yes, all of the above options are correct.