Question

10. (1 pr all or none) Concering methyl-directed mismatch repair circle all FALSE statements: a. In methyl-directed mismatch repair the strand that is repaired is the methylated strand. b. DNA Poll is required to fill in the repair gap. c. The Muth protein is directly responsible for recognizing mismatched base pairs.

Answer 1

In methyl- directed mismatch repair the strand that is repaired is not the methylated strand. It is unmethylated strand that is repaired.

MutS is the mismatch recognition protein. It has ATPase activity to beak the bond and remove the mismatch. It recognizes base-base mismatch, deletions, insertions etc in the DNA molecule. MutL binds to MutS and together activate MutH.

DNA pol is needed to replace the correct nucleotides.

a and c are false statements. b is right statement.