Question

Why is Streptomycin only effective against bacteria, and not archaea as well? I thought its mechanism of action had to do with its binding site on the 30S ribosomal subunit, but archaea have this as well, so why is it not effective against both?

For reference, I was asked to explain how the mode of action of each antibiotic relates to the organisms in each domain.

is down partenere a cyclo acteria on the basis of sensitivity to antimicrobial chemicals. The predicted antibiotic nsitivities are tabulated below: shuts down peptidye proton santhan putem synthesis inhinoh potearghs trans transfuase sustenin mbegones innibitor by interfein, w Streptomycin Anisomycin Cycloheximide Thiostrepton poren Bacteria elengetion Eukaryotes Archaea + 1 factor + + + + rials: binds to '{l site d 605 ribosomal

Answer 1

Question . why is streptomycin only effective against bacteria and not aschaen as well? I thought to mechanism of action had to do with its binding site on the 30s sibosomal subunit but archelen have this os well so why it not effective agant both ? for refernce I was asked to explain how the mode of of each domain. Answer.. Streptomycin stops bacterial growth by damaging t cell meonboences and inhibiting pootein synthesis Specifically, it bind to 165 ORNA of bacterial ribosome . interfering with the binding of foomy) - methinyl - tRNA to the 30's subunit . This paevents inition of the protein synthesis. Stoeptomycin in archaee poodud resistence to antibiotics Archaee are characterized by theid bocad - Spectoum desistance to antimicrobial agent. In particular their cell Wall lacks peptidoglycon, making them resistant to antimicrobial agent inter- fering with peptidoglycan biosynthesis.