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QUESTION 1 Women with mutations in their BRCA1 or BRCA2 genes are more likely to suffer from breast or ovarian cancer at some

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Answer - Incomplete Penetrance

An allele is described as a complete penetrance if all individuals possess the mutation that leads to disease condition eg- Autosomal dominant disorder.

An incomplete is a reduced penetrance in which some individuals will not express the trait even though they carry the allele.

Example - In breast cancer which is caused by mutations in the BRCA1 gene is Incomplete Penetrance because females with a BRCA 1/2 mutation in this gene will have an 80% risk of developing breast cancer and not 100%. Hence it is Incomplete Penetrance of 80%.

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