Question

Hendellan Genetics 'roblem 3.24 101 of 103 > A wrongful birth case was recently brought before a court in which a child with Smith-Lemli-Opitz syndrome was born to apparently healthy parents. This syndrome is characterized by a cluster of birth defects including cleft palate, and an array of problems with the reproductive and urinary organs. Originally considered by their physician as having a nongenetic basis, the parents decided to have another child, who was also bom with Smith-Lemi-Opitz syndrome. In the role of a genetic counselor, instruct the court about what occurred, including the probability of the parents having two affected offspring, knowing that the disorder is inherited as a recessive trait. Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Reset Help Most likely the attending shysician misdiagnosed the syndrome of the first child by teling the parents that the birth defects were not genetic. Given the birth of the second child with Smith Lomi-Opitz syndrome, it is highly likely that both parents were carriers for a gene causing SmithLemi-Opitz syndrome Under that circumstance, there is a percent chance that each of their children would be probability that two children of heterozygous parents would be unaffected recessive lected beats, Ihmark perfect 0.0313 0625 0.125 0.0156

Answer 1

Most likely the attending physician misdiagnosed the syndrome of the first child by telling the Parents that the child defects were not genetic. Given the birth of the secoond child coith Smith - Lemi- optiz syndrome, it is highly likely - that both parents coere carriers for a recessivel gere coming Sraitha Lemi - Opitz circumstances, there a [25 percent chance that each of their children could be affected. The probability Lemi le . is Under that

- that the two children of heterozygotes . parents could be affected could be [0.25] x [ 0.251 - 10.0625] or a E little over [6 percent Explanation: Smith. Lemi - Opitz Syndrome is an audos mal recessive disoder. Let allele 'A be the dominant allele responsible for the normal phenotype and 'll be the recessive allele responsible for the Smith-Lemi - Opitz Syndrome. So, following genotypes and phenotypes are possible: AA = Normal A a = Normal but Carrier a a = affected Here, Genotype of mother a a Genotype of Father = Aa Aa

Parents: Aa x Aa Gametos: Gameto: @ @ @ @ e offsprings: A A Aa Aa aq affected So, there is too (20.25) chance that the . offspring will be affected. - Hence, probability of 1st child to be affected = 0.25 of 251. 1st and 2nd both child Hence, probability of to be affected =txt= to = 0.0625 or 6.25.4.

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