Question

Incorporate the protection and deprotection of ketones, aldehydes, and alcohols in syntheses. 6. The following reaction will not go as protection/deprotection that will improve the outcome of the synthesis planned. Devise a plan for NaSCH3 H3CS Br

Answer 1

When two functional groups are capable of reacting with same reagent but we want only one functional group to undergo reaction then we protect the other functional group by using protecting group which can be removed by acidic hydrolysis later after completion of reaction of desired reaction.

NaScH3 BV CHAS since saiz is a nucleophile which can attack at Cartoonyl carbon as well so reaction will not undergo as planne planned. In order to carry out reachion as planned, first we will protect carbonyl group. 0 1 S renew HSẠCH,°F *H (Protection) After with that carbon add NascH3 which will react bearing halogen. (Bromine) 1 ς ς Nas CH₂ SH Hoot (deprotection 8 - , , , + HSL Required product