First of everything is going in right track except 3 and 4.
3 is Hoffman bromamide rearrangement and gives primary amine.
4 is amide formation.
What's the major product in each step of the reaction? e) 1. NaOEt, EtOH dilute OEt Eto 2. HyO*, heat 1. LiAIH4, ether 1. DIBAL, THF 2. H', H2O h) 1.2 eq. CH,CH2MgBr, ether 2. D3O OCH, 1) OH, H20 3) EtOH, H,o* 2) H,o 4) excess CHMgBr 5) H,O
Y EtOH 01) OEt 2) OEt Eto > + O 3) OEt Eto o 4) OEt 'OEt
CHM 2430 FA 2017 0 LDA - H2O 0 Na OEt H20 Intramolecular Aldol CHI 120 1. LDA β-keto ester 1. Na OEt, EtoH 2. H30* C7H120 1. LDA 0ヘ β-keto ester- 10. provide the mjor organic product for each box (via each transformation): (5 pts, 0.25 pt each) 1. LiAIH4 H30* NH2 cat. Hyo cat. H3o* CH3CH2-MgBr 2. H3o
2) CHs LDA 1) LDA 3 2) Ci OH, H20 -OH, H2O CHO 1 LDA 2) CH3CH2Br Он, H2O 1) NaOEt 8 2) NaOEt OEt 10 Cl NaH 2 (excess) 12 HO Bra(excess) 13 HO LDA 14L THF, -78 C NaOEt, EtOH NaOEt, EtOH 16 NaOEt, EtOH 17 Br но 18 OOEt 1)NaOEt, EtOH 2) H3O 19 OEt 20 l HO o CHO + H20
1. Predict the major product for the reactions shown below; pick any 5: HO xs CHal Ag20 NaOEt EtOH, Δ -H2O HO но он 0 он H2SO4 H20, A heat 1) PhMgBr 1) NaOH, Br2 2) 5% HCI 2)H3O+, Δ OEt 1) PPh3 3) KOtBu 2) O 1) NaOH on. Br 2) O o 1. Predict the major product for the reactions shown below; pick any 5: HO xs CHal Ag20 NaOEt EtOH, Δ -H2O HO но он 0 он...
Organic Chemistry 3) Propose a stepwise mechanism for the following transformations- NaOEt 0 EtOH H OET + CI Et 4) Propose a stepwise mechanism for the following transformations H2O+ HO.O. OH shi Ho Hogan
NaOEt OET ETOH HCI H2O NaOH H2O 1. LIAIHA 2. H20 CH420 Question 2 (1 pt) When treated with aqueous NaOH, the following compounds give an aldol product which then undergoes dehydration to give a new product (with Estereochemistry). Please give structural formulas for both products. NaOH NaOH + H20 Н20 H20 Aldol product Question 3 (1 pt) How many different aldols (B-hydroxyaldehydes), including constitutional isomers and stereoisomers, are formed upon treatment of propanal with a base?
CHy Ha, Pt, ethanol 2000 pa, rt CHy HBr, H20 CH N BH oic acid HyC CH CH 250 C .NaH, THF OH CH,CHCH +ICH-CH heat O" I. LDA 2. CHjCH2CH2CH2Br 1. HNO3. H2SO4 2. Br2, FeBr 3. Mg, ether 4. D20
Hi I need help predicting the products for these reactions OEt NaOCH.CH CH,CH OH b. H, O/H,0 a. NaOCH.CH CH,CH,OH b. Br c. NaOHH O, beat d. H2O*/H2O 1. NaCN, DMSO 2. CH,MgBr, Eto 3. H.O/H,O EN 2. NaH, CH,Br chemoselective 1. a. NaOet, EtOH Br b. 2. a. NaOH/H,O, heat b. H30+/H20 CY.NECEN cy OH b. then add HC-NH2 a. NaCN, DMSO b. HO*/H,0
Draw the products formed in the reactions below: 1) LDA 2) 3) H20 NaOCH3 b CH3OH, heat oo OEt с + N EtOH NH3, H20 d 요 NaBH3CH pH=2-3 1)KOH NH CI 2) 3) OH, H20 NaNO3 NH HCI