Synthesis starting with toluene starting with benzene and using a protecting group at some point in...
Starting with benzene or toluene, outline a synthesis of each of the following compounds using diazonium salts as intermediates a) 3,4,5-Tribromobenzonitrile b) 2,6-Dibromobenzoic acid
For the compounds named below, (1) draw the structure of each compound (2) using benzene or toluene as the only aromatic starting material devise a synthesis of each compound. b. p-nitroethylbenzenec. p-bromonitrobenzene d. p-isopropylbenzenesulfonic acid
12. Propose a synthesis for the following compound using benzene or toluene and any other reagents necessary. Show all major intermediate compounds that would probably be isolated during the course of your synthesis. (6 points)
6. Starting with benzene and using any other necessary reagents of your choice, design a synthesis for the following compound. Note: there may be more than one plausible answer 7. Starting with benzene and using any other necessary reagents of your choice, design a synthesis for the following compound. Note: there may be more than one plausible answer 8. Starting with benene and using any other necessary reagents of your choice, design a synthesis for the following compound. Note: there...
Design a synthesis for 1-bromo-4-methyl-2-nitrobenzene using benzene as the starting material. You can handwrite everything. Please show the structures of the intermediates after each step as well as the reagents used. (NOTE: you can NOT use Friedel-Craft alkylation after Nitration.) ALSO, Professor said: ch3Br/FeBr3 --> Br/FeBr2 --> HNO3/H2SO4 OR Br2/FeBr2 -> CheCL/ALCL3 -> HNO3/H2SO4 would NOT work. Hint: need protecting group
Protecting groups are used in synthesis when a starting material contains multiple reactive sites. This neutralizes one of the reactive sites and makes it inert to the reaction conditions. The protecting group can then be selectively removed to re-form the reactive site. Analyze the molecule below and answer the three questions. Identify the protecting group. Which reagent was used to install this protecting group? Which reagent is used to remove the protecting group? H3C CH3 Si CH3 CH3 CH3
5) Propose a synthesis of the following molecule, which will involve using an acetal protecting group, forming a Grignard reagent and performing a nucleophilic attack on a separate carbonyl compound. This will be a multi-step synthesis.
Can someone propose a synthesis of m-cresol from benzene or toluene using nucleophilic aromatic substitution. We haven't learned double-Wolff Kishner or Sandmeyer rxn so these aren't suitable.
Starting with toluene, propose a plausible synthesis of benzocaine.
Calculate the normal boiling point of i) benzene and ii) toluene using the Antoine equation. Compare your results to literature values for the two species.