Question

Protecting groups are used in synthesis when a starting material contains multiple reactive sites. This neutralizes one of the reactive sites and makes it inert to the reaction conditions. The protecting group can then be selectively removed to re-form the reactive site. Analyze the molecule below and answer the three questions.

H3C CH3 Si CH3 CH3 CH3

Identify the protecting group.

Which reagent was used to install this protecting group?

Which reagent is used to remove the protecting group?

Answer 1

Concepts and reason

If the starting material has more than one reactive site, protecting groups are used in organic syntheses to mask the undesired functional groups and make them inert to the reaction conditions. Finally, protecting groups are removed to regenerate the active sites back.

Fundamentals

The organic reactions are involved in the conversion of one functional group to another functional group in the starting material using a wide variety of reagents.

Protecting groups for alcohols:

(1)

Protection of alcohol functional group:

(2)

Reagent was used to install the given protecting group:

(3)

reagent is used to remove the protecting group.

Ans: Part 1

The protecting group is

Part 2

The reagent used to install this protecting group is

Part 3

The reagent used to remove the protecting group is