PREPARATION OF PHARMACEUTICALS - Fischer Esterification Reactions
Q: Calculate the expected mass of both methyl salicylate and aspirin assuming 100% yield.
PREPARATION OF PHARMACEUTICALS - Fischer Esterification Reactions Q: Calculate the expected mass of both methyl salicylate and aspirin assuming 100% yield. EXPERIMENT7 PREPARATION OF PHARMACEUTICALS...
Pre-lab Questions: Importance A one-step preparation of aspirin from its precursor, salicylic acid, via an ester formation illustrates one of synthetic organic chemistry's most important uses, making the drugs that treat all types of illnesses. OH HOOH Background Aspirin is a prodrug of salicylic acid, the actual active drug. A compound related to salicylic acid, salicin, was first isolated from willow bark in the mid 1700's, but willow-bark extract was used by the ancient Greeks as a treatment for pain...
find the theoretical yield of the acetysalicylic acid . EXPERIMENT 19 PREPARATION OF ASPIRIN In addition to the Fischer esterification method presented in Experiment 18, a second method for preparation of esters involves the reaction of anhydrides with the hydroxyl This method is ospecialy usoful for tho preparation of acetate esters, since acetic anhydride is an inexpensive and reactive reagent. In this experiment the hydroxyl group of salicylic acid is acetic anhydride to make acetylsalicylic acid, or aspirin. The short...
for this experiment of syntheis of aspirin, was the product obtained pure (based on color)? how do you know? the color was white Experimental Procedure HAZARD: Sulfuric acid, acetic anhydride and glacial acetic acid are corrosive to the skin. They are also irritants, and all operations in which these substances are used should be carried out under the hood. Prepare a hot-water bath by heating a 400-ml beaker containing about 200 mL of water. 1. Use a centigram balance and...
i did the synthesis of aspirin experiment and got the data below. how do you do the theoretical yield? percent yield of the pure aspirin? DATA: Mass of Salicylic Acid: 2.034g Volume of Acetic Anhydride used in synthesis: 4.00ml Mass of filter paper: 0.196g Mass of filter paper plus Aspirin: 1.868g Mass of Aspirin: 1.672g Percent Yield of Pure Aspirin: I Experimental Procedure HAZARD: Sulfuric acid, acetic anhydride and glacial acetic acid are corrosive to the skin. They are also...
Place 3.0 g of salicylic acid in a 125-ml Erlenmeyer flask. Carefully add, stirring constantly, 6 mL of acetic anhydride, followed by 10 drops of concentrated sulfuric acid. Swirl the contents of the flask so that the reactants are thoroughly mixed. Stopper the flask with a one- hole cork fitted with an inverted Pasteur pipet to prevent condensation of water in the reaction flask during heating on the steam bath. Heat the flask in a boiling-water or steam bath for...
1) Which reactant, salicylic acid or acetic anhydride, is in excess? Show your work. 2) If you were to use 3.17 g of starting material, how much product would you expect? Again, show your work. 3) Why is phosphoric acid added to the reaction? 4) A small amount of water is added at the end of the reaction to react with the excess acetic anhydride. Show a balanced equation for that reaction. 5) Explain the purpose of the FeCl3 test...
For the nitration of methyl benzoate: a. Which product did you get? What evidence do you have for this? b. Was your product pure? What evidence do you have for this? Explain your evidence. c. Draw the mechanism for the product you got. For the bromination of acetanilide: a. Which product did you get? What evidence do you have for this? b. Was your product pure? What evidence do you have for this? Explain your evidence. c. Draw the mechanism...
please help Mustrates treat all types of ilnesses. Background Aspirin is a prodrug of salicylic acid, the actual active drug. A compound related to salicylic acid, salicin, was first isolated from willow bark in the mid 1700's, but willow-bark extract was used by the andient Greeks as a treatment for pain and fever. Salicylic acid (and many related phenols) are very hard on your Ho stomach, but when esterified, as aspirin is, they are much better tolerated. Simple esters are...
used. Experimental . Place 2.0 g of salicylic acid in a 125-mL conical flask. 2. Add 4.0 ml (d = 1.08 g/mL; 4.3 g) of acetic anhydride and 6-8 drops of 85% phosphoric acid. 3. Swirl the flask to mix all reagents, and place it in a 70°C water bath. Heat for about 10 minutes. 4. Remove the flask from the water bath and add 2 mL of cold water drop- wise, swirling the flask after each addition, 5. Add...
how to calculate the expected mass of 1-bromobutane assuming 100% yeild experiment 4 preparation of 1-brokobutane A nucleophilic substitution reaction 2. Draw he structure of steps, and place MW 137 BP 101 C Density 1.275 bt There are other methods of producing allyl halide products from 1:00 n oven 1:00 0:15 Purification When all the suur ac has been added, remove from the ice water bath and off the outside of the fask Ad some boling ohips, fit a reflux...