Question

A) A cat has a daily dose of fluoxetine (Prozac) to treat her anxiety. When her owner goes out of town, the pet sitter is unable to get her to take her medicine. After missing five days of medicine, what percentage of the therapeutic level remains in the cat’s blood? The half-life is 55 hours. Assume the drug is metabolized according to first-order kinetics.

B) The anticancer drug cis-platin hydrolyzes in water with a rate constant of 1.5 × 10−3 M-1 min−1 at pH 7.0 and 25°C. If a freshly prepared IV solution of cis-platin has a concentration of 5.3 x 10-2 M, what will be the concentration of cis-platin after the IV sits in the pharmacy for 48 hours?

Answer 1

Solution as per given in the question let initial concentration of floxetine a boom te : 55 hours ka 0.69 3 hours t = 5 days or 5X24 = 120 hours using first order Kineties += 2.35 log Co 1205 2.363 855 log G 0.691 Oido 0.654= 2 28 = log ser = 4.51 Į x 10o = 22.1734 4.5 ® (ki sate Constant for hydrolysis of Cis-platin- R 1.5x 103 mt mint or goxig3m thour! from k it is clear that it is and order Kinetic Reaction . initial Concentration CG= 5.3810 2M (4=? t=u8 hours to the le-bo] - Mónicat la fase com] 48*904103 = that they X 16? Sowing 1/4 = 23.187 or 4= 4.313 x10²4