Provide examples of 3 reactions that produce compounds containing two new chiral centers from starting materials that contain no chiral centers.
Provide examples of 3 reactions that produce compounds containing two new chiral centers from starting materials...
6. Drugs often contain chiral centers. When that is the case, it can be critical to make them chiral in a useful way so that they have the desired biological effect. Two examples below illustrate this. With your developing expertise, you should be able to identify the chiral centers and apply the appropriate Rand S nomenclature to the levo- and dextro-rotatory forms of the compounds below. HECO nihon (+)-ethambutol used to treat tuberculosis levomethorphan - a potent oplod analgesic N-CHydor...
) Using only reactions learned in class, synthesize the following products from the starting materials that are shown using organic compounds that contain no more than two carbons. More than one step will be required. Show all reagents and intermediates along your synthetic pathway (10 points). HO Ph Ph
1. Provide the appropriate Wittig starting materials used to form the following product. Stereochemistry must be included where appropriate: 1.) Triphenylphosphine 2.) 50% NaOH, H20 2. Provide a synthesis of the following compound using the alkene provided as your only source of carbon. Multiple equivalents of the alkene can be used. You may use triphenylphosphine, and any additional inorganic reagents required as well. You may use any other carbon containing reagent as well, provided that it is not used as...
12. Please provide the two starting materials for both of the following reactions (A & B are two different questions): A) Ht heat NH B)
V Using Models of Compounds with Two Chiral Centers 25. On your drawing, use arrows to indicate the at- oms that could be chiral centers (34). 23. Construct a model of 2,3,4-trihydroxybutanal, as shown in Figure 4 26. Make a template for the atoms attached to carbon 2 in the molecule. The groups of atoms attached to carbon 2 may not touch the paper, but you can still mark their relative positions (35). OH OH HI H-C C aC 27....
Wittig Reaction Lab: Provide the appropriate Wittig product(s) formed from the following starting materials [assume the addition of aqueous sodium hydroxide in order to create the reactive ylide intermediate]. Clearly indicate any chiral centers and E/Z isomerism: a) o-methylbenzaldehyde, triphenylphosphine, and (R)-1-bromo-2,3-dimethylbutane b) (S)-1-chloro-3-ethylhexane, triphenylphosphine, and cyclopentanone
Problem 2. Provide the structures of the starting materials necessary to form the following compounds via an aldol condensation, Claisen condensation, or Wittig reaction. Use each reaction once, and indicate which reaction you are proposing. For some reactions, there may be multiple correct answers (provide only one).
3. Provide the reagents necessary to carry out the following reactions or provide the starting materials or major products of the following reactions, Indicate racemic mixtures where necessary. (39 pts) 1)AIC осн, a. Ph 2) PaC H Н,со 45 1) HS0, HNO b. 2) Pd/c. H Н,со он c. Ph HO, он
3.14 Which compounds contain chiral centers? (a) 2-Chloropentane (b) 3-Chloropentane (c) 3-Chloro-1-pentene (d) 1,2-Dichloropropane 3.18 Mark each chiral center in the following molecules with an asterisk. How many stereo isomers are possible for each molecule? CH COOH CH 0 (a) CH CCH=CH, (b) HCOH (c) CH,CHCHCOOH (d) CH,CCH.CH OH CH NH CH,OH OH CH,COOH (e) HCOH () CHCH.CHCHECH, (g) HOCCOOH CH,OH CH,COOH
In the reactions below you are given a product and enough the starting materials information about the formation of the product to provide 1. Th followling as munde usiig a Dicls-Alder reuction Provide the rouctants and reaction conditiows The foliowing product was made starting with benzene -provide all steps of the reaction and reaction conditions 2. 3. The following was made in an enamine synthesis-provide the starting materials and reaction condit Aromaticity-3 points each Please classify the following compounds us...