Question

Given below is the structure of Pregabalin. Write the structures of the predominant species of this drug at pH values1, 7.2, and 13. In each case your structure must clearly indicate the correct ionixation states of various ionizable functional groups in Pregabalin.

01; when Δ change in ion Some useful pKa values to remember H3N H OH pKa ds and sol lled the he Pregabalin tion. If reactant 10.4 xothery are weal ndother s is con 4.7 ed in solvat s beca A) Stomach (pH 1.0) r is f ing e otic /or com ert B) Bloodstream (pH 7.2) is C) An aqueous buffer at pH 13.0

Answer 1

(e) Blood Stream (r. 7.2) eut midium) (c) An