Question

Compare   and   contrast   the   advantages   and   disadvantages   of   the   two   techniques   HPLC   vs. electrochemistry

for determination of vitamin C in multivitamin tablets

Answer 1

Determination of vitamin C in multivitamin tablets :

HPLC		Electrochemistry
Advantages	Disadvantages	Advantages	Disadvantages
Sensitive and precise with good linearity. LOD (limit of detection) is 2pmol/L	Inability to provide real time results	This are simple, inexpensive instrument and also involved procedures	Lacks specificity
Provide accurate quantitative results	Expensive method	Low detection of limit with high selectivity	slow analysis time
Fast analysis time. Specific and high through put	Require careful selection of mobile phase and its sample flow rate	Microsensors, microvolume and micromeasurements are easy to apply	Lack of precision