Question

Pick the statement about mutation that is false. 

• Intercalating agents cause frameshift mutations. 

• Gain-of-function mutations are usually recessive. 

• The Ames test measures reversion frequencies. 

• Depruination of a nucleotide can happen spontaneously. 

• Tandem duplications can be generated by strand slippage during replication.

Answer 1

Gain of function mutations are usually recessive

Explanation:

Gain of function mutations are dominant as one copy in a heterozygote can alter the normal phenotype.

Loss of function mutations are recessive as one copy in heterozygote can produce the wild or normal type phenotype.

Intercalating agents insert between DNA bases and causes frameshift mutation.

The Ames test is used method to test the chemical that causes mutations in the DNA.

Depurination means loss of prime bases such as adenine and guanine and it can occur spontaneously.