Problem Draw the organic products formed in each reaction. Cill ? Br2 b. C. HBr HBr ROOR d. e. Br NBS ive
Predict the major products of following reactions NBS, heat C. CClA Br2, heat CClA d. Cl2, light CCI4 e. NBS, heat CCI4
3. Predict the product(s) of the following reactions. + HBr a) light + Br2 b) c) dehydration of alcohol: H.SO heat 3,3-dimethyl-2-butanol d) +Br2 e) B-elimination Br CH,OH +NaOCHs HighTemperature +Br f)
What is the major product obtained from the following reaction sequence? Br2 EtONa NACN D HBr B A ETOH hv peroxides heat CN CN CN CN II III O A. III OB. IV O C.V OD II O E. I What would be the major product of the following reaction sequence? 1. HBr, ROOR, hv 2. CH CO-H, CH coNa OH 0.CCH 0.cCH Ph Ph I III IV O A.I O B. II O C. IV O D. II O...
match the right reagent 3 OH + enantiomer + enantiomer 5 CO A.) PBrs B.) NBS, hv C.) D.) NaOH E.) NaNH2 F.) Br2 G.) HCI H.) Cl2, H2O 1.) HBO J.) H2 (1 eq), Pt K.) Na, NH3 L.) H2SO4, H20 M.)1. Hg(OAC)2 0.) N.) 1. mCPBA 2. H+, H2O 2. NaBH4 P.) 1. BH3 2. H2O2, NaOH 3 OH + enantiomer + enantiomer 6 CO A.) PBrs B.) NBS, hv C.) D.) NaOH E.) NaNH2 F.) Br2 G.)...
4. Draw the structures of the compounds formed in the following synthetic schemes. Br2 (CH3)2CHCH2CH3 UV NaOEt HBr C ROOR 1. Br2 E KOTBU ETOH 2. NaNH2(xs) 3. Нао light a. OH CHCH3 TsCl -сHа HBr B ROOR Кови A На C NaCECH 1. BH E 2. H2O2 NaOH F base Lindlars catalyst b. Br NaOMe HBr A ROOR 1. Br2 с 2. NANH2(xs) 3. H2O KOtBu В (CH3)2CCH2CH3 D MeOH с. Br2 NaOMe HBr c NaC CHD На (CH3)3CH...
Question 6 How would you accomplish the following synthesis? HC HO CH. A 1. NBS, light 2. NaOH 3. Ti[OCH(CH3)214 (-)-DET to-oh 1. H2, Pt 2. HBr, ROOR 3. MCPBA -OOH D None of the above с МСРВА
1 eq HBr 1eq Br2 1eq NBS hv KMnO4 heat Rh/C H2, moderate press.
Post-Lecture Quiz Q#4 Worksheet 19.3 Q3(c) Propose an efficient synthesis for the transformation below ОН OH Hint: This one does NOT involve a Wittig reaction See last slide for reagent options Post-Lecture Quiz Q#3 and Q#4 Reagent options (a) LAH, then H20 (b) H30*, heat (c) PhyP CH2 (d) Ph3P-CHCH, (e) Phyp-C(CH3)2 () Hg(OAc), H20 then NaBHA (h) BH, THF, then H2O3, NaOH (1) HBr + ROOR (1) MCPBA (6) KCN, HCN (1) Formaldehyde (m) Acetone (9) PCC
4. Design a synthetic plan for the following conversions; Meaning you need to write each reaction product for each step presented on the arrow. First one is solved as an example он ОН (meso) 1. H2S04, heat s O NaHSos H20 cys hydroxilation он E1 OH (meso) 1. HBr, ROOR b) (rac) 1. Br2, hv 2. KOH, EtoH 3. mCPBA/ H3o* (rac) d) 1. NBS, hy (rac) 3. K*tBuo, EtOH 4. Hg(OAC)2 CH30H/ NaBH 1. H2SO4, heat e) 2. mCPBA...