Question

Problem 7 The uricosuric drugs (increase urination of uric acid/ anti-inflammatory) Butazolidine and Anturane are active in the anionic form. As the anions, these drugs block re-absorption of uric acid by renal cells. Draw the anionic forms of each drug. If the potency of the drug corresponds to the relative anion concentration, which drug would be the most affective medication. Calculate the approximate relative potency of one drug over the other. (The pH of urine is 4.8). Butazolidine Anturane pk = 28

Answer 1

Answer :)

O, H O H N- H H O-S Butazolidine Anturane pka 4.2 pk, 2.8

The image contains all anion forms in one structure, which can interpret as different anion forms. Butazolidine contains two mesomeric anions types while Anturane contains three anion forms.

Therefore, Anturane has relative potency for anionic form as 3 while the drug Butazolidine has potency 2.

The relative potency of Anturane to Butazolidine = 3/2

The relative potency of Anturane to Butazolidine = 1.5

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