1. Determine whether the following reactions go through SN or SNP and write the products, with...
1. Show the products of the following Sn2 reactions, including stereochemistry. Note: In all three cases, the solvent does not directly participate in the reaction (again, the solvents differ just so that the respective reactants all dissolve) and, as always, Nat is simply a spectator ion. a) EtOH Branche + NaOE EICH Hz + NaOEt acetone + Nal Phi Ph DMSO C YCHz + NaSH
1. Determine whether the following reactions will go through SN1, SN2, E1, or E2 mechanism a. 1-bromobutane + sodium hydroxide b. 2-chloro-2-methylpentane + sodium hydroxide + heat C. 2,3-dimethyl-3-bromopentane + water d. 2-bromobutane + methanol 2. Draw the major product for the following reactions (draw both products if racemic): NaSH DMSO TsO CHA Nal CH, acetone CH,CH,ONa+ ethanol CH,OH/H-0 Solite Nal (1 equiv.) acetone F CH2CH OH 25°C
7. Draw the structures of the products P1 and P2 for the two SN 2 reactions shown. Make sure to indicate the stereochemistry in the products correctly! What is the most appropriate description for the role of the polar aprotic solvent (DMSO) in each reaction? KCN NASH → P1 By → P2 DMSO DMSO For questions 7 - 10: to practice for the exam: draw the reaction-energy diagrams for these reactions, writing out the specific rate equations for each of...
2. Predict whether the reaction willl go by SN1, SN2, E1, or E2, or some combination of these. Explain. Also give the products with correct stereochemistry if applicable. SoI Na CN Br dimethyl sulfoxide (DMSO) CI CH,онн,0 Br CH3S Na* + acetone
Complete the following reactions and determine whether the reaction proceeds by an Sn 1, SN2, E1, or E2 mechanism and place the answer to the left of the reaction. Show stereochemistry where relevant. whether the reaction proceeds by an x1, Sa CH3 Br Br o NON DMSO da Нас сн H3C Br --BrH-Cecna O* DMF CH30® Na CH3OH, 50°C
1. Provide the products of the following reactions. Write N.R. if there is no reaction happens. NH2 Nal Acetone CH COONa - foto 57 NaOM NaSH DBU EtOH NaCN EtONa Me- Br -Me
6. For the following reactions tell whether they will react under Ss1 condition (EtOH, heat), Ss2 condition (Nal/acetone) or neither. Also indicate the product formed if any. (10 points) Mechanism Product (Sl or S2) Br TsO HaC ii. Br Br HC iv. H3C CH3 H3C OCH3
z:o. z:0-( zin- 7. Draw the structures of the products P1 and P2 for the two Sk2 reactions shown. Make sure to indicate the stereochemistry in the products correctly! What is the most appropriate description for the role of the polar aprotic solvent (DMSO) in each reaction? KCN NaSH P1 Br P2 DMSO DMSO Br For questions 7-10: to practice for the exam: draw the reaction-energy diagrams for these reactions, writing out the specific rate equations for each of the...
2. (16 pts) Reactions Provide reagents, products or starting materials for the following reactions. Show stereochemistry when relevant (or loss thereof). If a reaction produces no significant products, write "NR". If you have a question about an abbreviation, just ask. NaBr OH 1. TsCI 2. Nal, DMF CI DMSO OH 1. PBrg NaCN 2. KOC(CH3)3 Ether LDA НОН THE NaH NaH PO Acetone Heat, water
1) Predict the outcome of the following 4 reactions 1) Predict the outcome of the following 4 reactions MeOH Ph reflux XPh MeΝΟ, reflux Y Br MeNO2 MeSNa DMSO Ph reflux Br 2) For the following 5 molecules predict whether an E2 elimination would be possible for the DRAWN conformation. Do not attempt to rotate around any bonds, judge based on the conformation shown. If yes, show the product. Br Ph BCH Meph Me Y y o tadi men 3)...