Question

The image below shows the reactions of the Beta-oxidation pathway. Label the reaction types on the...

The image below shows the reactions of the Beta-oxidation pathway. Label the reaction types on the diagram.
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Answer #1
Concepts and reason

A sequence of reactions is given for the βoxidation{\rm{\beta - oxidation}} pathway and each step of the reaction needs to be mentioned with the reaction type. Observe the reactant and the product of each step and identify the type of reaction by looking at the changes in each step.

Fundamentals

Consider the given type of reactions as follows:

• Oxidation reaction: It refers to the addition of oxygen or elimination of hydrogen from the compound.

• Hydration reaction: it refers to the addition of water molecule to a compound.

• Cleavage: It refers to the removal of a part from a compound by breaking of bond.

Consider the first step of the given sequence of reactions and write the type of reaction it follows as shown below:

RH2CH2C
-S-CoA
Аcetyl
FAD
oxidation
FADH2
H
RC
Н
-S-CoA trans-a, B-Enoyl-CoA (or trans-A2-enoyl-CoA)

Consider the second step of the given sequence of reactions and write the type of reaction it follows as shown below:

|D1
RC C
-S-CoA trans-a, ß-Enoyl-CoA (or trans-A2-enoyl-CoA)
hydration
Н,0
ОН
На
C
RC
L-B-Hydroxyacy-СоА
-CoA
н

Consider the third step of the given sequence of reactions and write the type of reaction it follows as shown below:

ОН
Н
RC—с—С—s—СoA
L-p-Нydroxyacyl-СоA
NAD
Н
Оxidation
NADH H
Н,
RC—с—С—s—СоA
В-Ketoacyl-CoA

Consider the fourth step of the given sequence of reactions and write the type of reaction it follows as shown below:

Н,
RC
В-Кetoacyl-CoA
-СоA
СOASH
Cleavage
RC—S—CоА Асyl-CoA + Acetyl-CoA H,С-
-S—СoA

Ans:

Hence, the type of reaction followed by first step is as follows:

RH2CH2C
-S-CoA
Аcetyl
FAD
oxidation
FADH2
H
RC
Н
-S-CoA trans-a, B-Enoyl-CoA (or trans-A2-enoyl-CoA)

Hence, the type of reaction followed by second step of given reaction sequence is as follows:

|D1
RC C
-S-CoA trans-a, ß-Enoyl-CoA (or trans-A2-enoyl-CoA)
hydration
Н,0
ОН
На
C
RC
L-B-Hydroxyacy-СоА
-CoA
н

Hence, the type of reaction followed by third step of given reaction sequence is as follows:

ОН
Н
RC—с—С—s—СoA
L-p-Нydroxyacyl-СоA
NAD
Н
Оxidation
NADH H
Н,
RC—с—С—s—СоA
В-Ketoacyl-CoA

Hence, the type of reaction followed by the last step of given reaction sequence is as follows:

Н,
RC
В-Кetoacyl-CoA
-СоA
СOASH
Cleavage
RC—S—CоА Асyl-CoA + Acetyl-CoA H,С-
-S—СoA

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