Question

PrintCalculator Periodic Table n 5 of 32 MHE/Freeman netics: A Conceptual Approach 6th Edtion Both genetic and nongenetic factors cause the congenital skeletal abnormality known as clubfoot, which in which occurs with a worldwide incidence of about 1 in 1000 births. Gurnett et al. identified a clubfoot occurred as an autosomal dominant trait due to a mutation in the PITXI gene. DNÁ testing revealed that 11 people in the family carried the PITXI mutation, but only 8 of these people had clubfoot Calculate the penetrance of the PITXI mutation in this family Number Lower-Limb Malformations in Individuals with Homeobox PITX1 Gene Mutation. Am J Hum Genet 200B, 83 616 O Pravicus Give Up & View Solution Check Answer NextEx

Answer 1

72.72% of penetrance happened.

Reason : out of 11 members the family where all are the carriers but the gene was active only in 8 people the percentage of 8/11 people gives you 72.72%. which is the rate of penetrance of the gene in the family.