Question

A chemist at a pharmaceutical company is measuring equilibrium constants for reactions in which drug candidate molecules bind to a protein involved in cancer. The drug molecules bind the protein in a 1:1 ratio to form a drug-protein complex. The protein concentration in aqueous solution at 25 ∘C is 1.72×10⁻⁶ M . Drug AA is introduced into the protein solution at an initial concentration of 2.00×10^−6M. Drug BB is introduced into a separate, identical protein solution at an initial concentration of 2.00×10^−6M. At equilibrium, the drug AA-protein solution has an AA-protein complex concentration of 1.00×10^−6M, and the drug BB solution has a BB-protein complex concentration of 1.40×10^−6M.

a)Calculate the Kc value for the AA-protein binding reaction.

b)Calculate the Kc value for the BB-protein binding reaction.

Answer 1