A.Calculate the Kc value for the A-protein binding reaction.
B.Calculate the Kc value for the B-protein binding reaction.
C.Assuming that the drug that binds more strongly will be more
effective, which drug is the better choice for further
research?
Homework Answers
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A.Calculate the Kc value for the A-protein
binding reaction.
B.Calculate the Kc value for the B-protein...
A chemist at a pharmaceutical company is measuring equilibrium constants for reactions in which drug candidate...
A chemist at a pharmaceutical company is measuring equilibrium constants for reactions in which drug candidate molecules bind to a protein involved in cancer. The drug molecules bind the protein in a 1:1 ratio to form a drug-protein complex. The protein concentration in aqueous solution at 25 ∘C is 1.72×10−6 M . Drug AA is introduced into the protein solution at an initial concentration of 2.00×10^−6M. Drug BB is introduced into a separate, identical protein solution at an initial concentration...
A chemist at a pharmaceutical company is measuring equilibrium constants for reactions in which drug candidate...
A chemist at a pharmaceutical company is measuring equilibrium constants for reactions in which drug candidate molecules bind to a protein involved in cancer. The drug molecules bind the protein in a 1:1 ratio to form a drug-protein complex. The protein concentration in aqueous solution at 25 ∘C is 1.88×10−6 M . Drug A is introduced into the protein solution at an initial concentration of 2.00×10−6M. Drug B is introduced into a separate, identical protein solution at an initial concentration...
1. What does it mean to have positive cooperatively in protein-ligand binding? 2. The protein “Mariota”...
1. What does it mean to have positive cooperatively in protein-ligand binding? 2. The protein “Mariota” binds to the ligand “football” with an association rate of 8.0 x 10 103M-1s-1 and an overall dissociation constant, Kd of 10 nM. Calculate the dissociation rate, kd, including appropriate units. 3. An antibody binds to an antigen with a Kd of 8 X 10-6M. At what concentration of antigen will the fractional saturation (Υantigen) be (a) 0.2, (b) 0.5, (c) 0.6, and (d)...
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The reversible chemical reaction A+B⇌C+D has the following equilibrium constant: Kc=[C][D][A][B]=2.0 Part A Initially, only A...
The reversible chemical reaction A+B⇌C+D has the following equilibrium constant: Kc=[C][D][A][B]=2.0 Part A Initially, only A and B are present, each at 2.00 M. What is the final concentration of A once equilibrium is reached? Express the molar concentration numerically using two significant figures. Part B What is the final concentration of D at equilibrium if the initial concentrations are [A] = 1.00 M and [B] = 2.00 M ? Express the molar concentration numerically using two significant figures.
Drug Miracurol (molecular weight 540 daltons) binds to a key oncogenic proteins, Malevolin, with a dissociation constant...
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Part B please For the equilibrium reaction: PCI (g) =PC13(g) + Cl2(g); Kc = 0.00183 a. Write the concentration equilibr...
Part B please
For the equilibrium reaction: PCI (g) =PC13(g) + Cl2(g); Kc = 0.00183 a. Write the concentration equilibrium equation for the reaction. [1 mark] b. If 2.0 gram of PCis(g) is introduced into a 1.5 L flask what will be the equilibrium concentrations of PCls, PClz and Cl ? [4marks]
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Part B please
For the equilibrium reaction: PCI (g) =PC13(g) + Cl2(g); Kc = 0.00183 a. Write the concentration equilibrium equation for the reaction. [1 mark] b. If 2.0 gram of PCis(g) is introduced into a 1.5 L flask what will be the equilibrium concentrations of PCls, PClz and Cl ? [4marks]
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