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Chymotrypsin What evidence in chymotrypsin mechanism supports the claim that chymotrypsin catalysis involves general acid-base catalysis...

  1. Chymotrypsin
    1. What evidence in chymotrypsin mechanism supports the claim that chymotrypsin catalysis involves general acid-base catalysis and covalent catalysis?
    2. Draw the chemical structure of the transition state (resembles the intermediate structure) in the step that forms the enzyme-product covalent adduct.
    3. In comparison to the substrate, how is the tetrahedral transition state preferentially stabilized by enzyme?
    4. Chymotrypsin mechanism: Write all the steps in the mechanism and understand what each step accomplishes.
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