Question

An experimental drug is being developed to selectively inhibit TH cells to prevent organ rejection. How will this help patients?

When TH cells are inhibited, macrophages become less phagocytic and will not attack the donated organ.

By inhibiting TH cells, B cells will be able to proliferate extensively, allowing them to protect the donated organ from rejection.

Inhibiting TH cells will reduce the number of phagocytic TH cells in the blood which in turn will do less damage on the donated organ.

If TH cells are inhibited, TC cells fail to become active and will do less damage to the cells of the donated organ. If TH cells are inhibited, TC cells fail to become active and will do less damage to the cells of the donated organ.

Answer 1

I assume first two line is the question and rest are 4 options for answers. If my assumption is incorrect please comment.

According to the question an experimental drug is developed which is selectively inhibiting Helper T cells (TH cells) in order to prevent organ rejection. Helper T cells plays a crucial role in in our immunity system. It activates B cells to produce antibodies and enhance the activity of macrophages to kill the ingested microorganisms. Helper T cells also activate cytotoxic T cells (TC cells) to destroy cells which has been already infected by various means.

All the options in the questions are almost correct except the second option i.e.

By inhibiting TH cells, B cells will be able to proliferate extensively, allowing them to protect the donated organ from rejection (incorrect option) -

By inhibiting TH cells, these can not properly interact with B lymphocyte and then there will be no generation of B cells (no proliferation of B cells) as immune system become inefficient to develop affinity of their antibodies.