Explain the relationship between concentration of intracellular Ca2+ and the strength of cardiac muscle cell contraction. Explain the effect of Ca2+ channel blocker drugs on the contraction force of the heart.
Explain the relationship between concentration of intracellular Ca2+ and the strength of cardiac muscle cell contraction....
Diagram how an action potential generates contraction (excitation-contraction coupling) in a cardiac muscle cell. Compare and contrast cardiac muscle cell action potentials (both autorhythmic and contractile cells) and contraction with those in skeletal and smooth muscles. (be sure to discuss refractory periods & summation/tetanus in each type of muscle).
Release of acetylcholine from a neuron onto a striated muscle cell triggers contraction, release onto a heart muscle slows the rate of contraction, and release onto a pancreatic acinar cell triggers the release of digestive enzymes. How can acetylcholine have different effects on different cells? Different subtypes of the acetylcholine receptor activate different signal transduction pathways in different cells. Acetylcholine binds to intracellular receptors in some cell types, tyrosine kinase receptors in other cell types, and G protein-coupled receptors in...
Please answer all parts. Thanks in advance 19) Which statement(s) is(are) NOT true regarding cardiac muscle? Choose ALL that apply. (2.5 pts) a) Autorhythmic cells do not contribute significantly to the force of heart contraction because they do not contain many myofibrils. b) Cardiac muscle consists of autorhythmic fibers and contractile fibers. c) Cardiac muscle is similar to skeletal muscle since t contains thick and thin filaments, d) Cardiac muscle is similar to skeletal muscle in that the muscle fibers...
(a) Explain the physiological mechanism of excitation-contraction coupling in skeletal muscle. (b) Draw links between excitation-contraction coupling, EMG, and dynamometry.
There is a trade-off between speed and force in muscle contraction. a) Why does this trade-off exist (please explain in terms of force generation by myosin heads)? b) How do glycolytic muscle fibers circumvent this trade-off?
12. In a cell, the difference in ion concentration between the intracellular and extracellular fluids results from a. active ion transport. b. passive diffusion of ions. c. bulk movements of intracellular and extracellular fluids. d. both active ion transport and passive diffusion of ions.
Neuron Signaling and Muscle Contraction 1) “Dissect” the various parts of an action potential by describing the status (active or nonactive) of the voltage-gated sodium channel, voltage-gated potassium channel, sodium/potassium pump, and overall voltage and/ or voltage range (in millivolts, or mV) for each of the following. A) Resting membrane (prior to the initiation of an action potential) B) just before threshold to just after threshold (Depolarization) C) Rising phase of the action potential D) Falling phase of the action...
inhibit the flow of extracellular Ca 2 ions across cell membranes of cardiac cells, vascular tissue. They relax arterial smooth muscle, depress the rate of sinus node pacemaker, slow AV conduction, decrease heart rate, produce negative inotropic effect. is a class of drugs used to prevent the extension and formation of clots by inhibiting factors in the clotting cascade and decreasing blood coagulability; used
MY DOG IS BROKEN : ASSIGNMENT Nitroglycerin Nitric Oxide Guanylyl Cyclase (inactive) Smooth Muscle Cell GTP GTP Nitric Oxide . (N:0) Citrulline IN:O.Guanyl N:O-Guanylyl Cyclase (active) Inactive PKG Activated PKG ATP Nitric Oxide Synthase Phospho-Proteins Proteins Abbreviations: N:O: nitric oxide GTP: guanosine triphosphate CGMP: cyclic guanosine monophosphate PKG: CGMP dependent protein kinase ATP: adenosine triphosphate Сам L-Arginine Lowering of Ca2+ Desensitization to Ca2+ Endothelial Or Neuronal Cell Relaxation Ca2+ LOCALLY PRODUCED NITRIC OXIDE PDE5 INHIBITORS SEQUESTRATION EXPORT Са24 Ca2+ 5-GMP...
A researcher studies the relationship between taking aminoglycosides and muscle strength in a random sample of patients who take aminoglycosides and a random sample of patients who do not take aminoglycosides. An average strength score is calculated for each participant. To determine if there is a statistically significant difference in the average strength score an independent t-test is utilized. The researchers report that taking aminoglycosides is associated with a lower average strength score (t=1.984, p=0.025). You know this means: A...