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5. Why is the small intestine an important site of absorption for toxicants?

5. Why is the small intestine an important site of absorption for toxicants?

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Absorption for toxicants or any molecule in Digestive tract , depends on their fat solubility ( non-polar nature) in various parts of body. ( Lipid solubility and molecular size are important in determining how efficiently toxic substances are transported across the digestive tract epithelium and into the bloodstream. ) Proportion of charged or neutral form of a toxicant depends pKa of polar group present in toxicant molecules. In stomach pH is very low (-1-1.5) , thus most of toxic substances are in protonated form at that pH , thus major portion is water soluble , as it enters in small intestine pH increases to normal level thus fraction of Lipid soluble forms increase, and absorption in result.

Thus, Absorption of toxic substances in the digestive tract occurs primarily in the small intestine.

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