Question

How FAST do these processes occur? (destruction/metabolism of melatonin) please explain

1. What is the half-life, volume of distribution, and clearance of the hormone?  

Answer 1

Answer

Half life of melatonin is 35 to 50 minutes.

In humans, 90% of orally administered exogenous melatonin is cleared in a single passage through the liver, a small amount is excreted in urine, and a small amount is found in saliva.

A dosage of 0.5 mg will last only an hour while a 10 mg dosage will last more than seven hours.

6-Hydroxymelatonin glucuronide is the major metabolite found in mouse urine (65-88% of total melatonin metabolites in urine).