Question

*16. Give the subtype names for the theoretical influenza viruses described below?

(a) a reassortment between H3N2, which supplies all gene fragments except PB2, and Eurasian swine H1N1, which supplies PB2.

(b) a reassortment between seasonal H3N2, which supplies all gene fragments except NA, and Eurasian swine H1N1, which supplies NA.

(c) a reassortment between North American classical swine H1N1, which supplies the polymerase genes plus HA and NS (i.e. NS1, NEP/NS2), and the 1918 human H1N1, which supplied NP, NA and M.

Answer 1

Influenza A virus (IAV) contains following major structures:

• Haemagglutinin (HA)
• Neuraminidase (NA)
• Matrix 1 protein (M1)
• Matrix 2 (M2)
• Eight segments of negative sense
• NP — nucleoprotein
• PB1
• PB2,
• PA — polymerase subunits
• Ribonucleoprotein complexes (RNP)
• Non-structural protein 1 (NS1)
• Non-structural protein 2 (NS2)

a) Seasonal H3N2

b) H1N2 North American Swine flu- triple reassortment.

c) Pandemic H1N1