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Each human α-globin locus contains two α-globin genes, α1 and α2, and most individuals have two...

Each human α-globin locus contains two α-globin genes, α1 and α2, and most individuals have two copies of the locus. Which of the genotypes would result in the most severe phenotype? (A"–" represents a deletion allele.) Select one: a. α1 – / α2 – b. α1 – / α2 α2 c. α1 α1 / – – d. α1 α1 / α2 α2 e. α1 – / – –

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e . a1-/- - result in severe phenotype because in this a2 is completely lost and only copy of a1 is present . It is the trans deletion and result in haemoglobin H disease in which red blood cells are hypochromic. In this case haemoglobin function get altered and result in enhanced affininty for oxygen and make it no longer  available for the body.

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