Inactivation of protein P causes a disease D. The mRNA from the affected individuals in the...
Inactivation of protein P causes a disease D. The mRNA from the affected individuals in the same family had a deletion of 113 nucleotides. The comparison of the gene sequence between the affected and healthy individuals identified one nucleotide substitution. A) What could be the molecular mechanism that cause the deletion of 113 nucleotides in the mRNA? B) What can happen to the protein P as a result of this deletion? C) What can you conclude about the molecular basis of the disease D
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Inactivation of protein P causes a disease D. The mRNA from the
affected individuals in the...
A single nucleotide deletion in the DNA causes a protein change in sequence from Ser –...
A single nucleotide deletion in the DNA causes a protein change in sequence from Ser – Thr – Ile – Ser – Gly – Ala – Arg – Leu To Ser – Thr – Leu – Ala – Glu – Pro – Val What are the old and new mRNA nucleotide sequences?
Shown below is the anti-sense DNA sequence from a region of a gene that produces a...
Shown below is the anti-sense DNA sequence from a region of a gene that produces a specific protein. Mutations in this region of the gene cause a disease CTT TTA TAG TAG ATA CCA CAA AGG a. What is the mRNA strand that is transcribed from the DNA shown above? b. What is the amino acid sequence that would be translated from the mRNA strand you determined in part 1? c. If an individual has a G at position 15...
Dystrophin is a protein that forms part of a vital protein complex that connects the cytoskeleton...
Dystrophin is a protein that forms part of a vital protein complex that connects the cytoskeleton of a muscle fiber cell to the extracellular matrix. This connection strengthens and shapes the muscle fibers. Dystrophin is coded by the DMD gene. This is one of the longest human genes known, covering 2,300,000 base pairs (0.08% of the human genome) It is located in chromosome 21. The immature mRNA is 2,100,000 bases long and takes 16 hours to transcribe. It contains 79...
Review Questions BIOL 260: Chapters 8-10, 13, 19 1. Consider a mutation involving the deletion of...
Review Questions BIOL 260: Chapters 8-10, 13, 19 1. Consider a mutation involving the deletion of either 1, 2, or 3 nucleotides in the DNA of a bacterium. Which of these mutations (ie., deletion of 1, 2, or 3 nucleotides) would likely have the LEAST impact on the organism? Why? Include in your answer a comparison with the other two options to justify your reasoning. Think carefully about the impact each mutation would have on the ultimate protein coded for...
Overview The purpose of this activity is to help the students to understand how replication, tran...
TranslationOverview:The purpose of this activity is to help the students to understand how replication, transcription, and translation are connected. Students will use a sequence from a bacterial gene that confers resistance to antibiotics (carbapenems). They will be asked to apply the knowledge obtained in the class lecture to (1) find the promoter in the sequence, (2) determine the amino acid sequence of a fragment of the polypeptide, (3) "reverse translate" a fragment of the polypeptide, and (4) identify mutations in...
QUESTION 1 MC. Which of the following disease conditions might NOT be treatable by RNAI? a....
QUESTION 1 MC. Which of the following disease conditions might NOT be treatable by RNAI? a. arthritis b. Cancer caused by tumor suppressor gene mutation c. macular degeneration d. cancer caused by oncogen mutation S 5 QUESTION 2 MC. What is the molecular cause of male courtship behavior in fruit flies? a. Alternative splicing of the fruitless transcript b. RNA editing of the fruitless transcript C. Alternative sequence of the fruitless DNA d. Alternative 3' cleavage and polyadenylation of fruitless...
13. Why are ribonucleoside triphosphates the monomers required for RNA synthesis rather than ribonucleoside monophosphates? A....
13. Why are ribonucleoside triphosphates the monomers required for RNA synthesis rather than ribonucleoside monophosphates? A. Only ribonucleoside triphosphates contain the sugar ribose. B. Ribonucleoside triphosphates have low potential energy, making the polymerization reaction endergonic. C. Ribonucleoside triphosphates have high potential energy, making the polymerization reaction exergonic. D. Ribonucleoside monophosphates cannot form complementary base pairs with the DNA template. E. Ribonucleoside triphosphates are not used, rather all use deoxyriboside triphosphates. 14. How is a mutation in a bacterial cell that...
Case Presentation Jordan is a healthy twenty-six year old male. He is an only child, son of Jessi...
number 5 please
Case Presentation Jordan is a healthy twenty-six year old male. He is an only child, son of Jessica age 45 and Ryan 43. Jordan is married and has no children. Eight years ago, Jordan's mother was diagnosed with Huntington's disease, a hereditary disease that destroys neurons in the basal ganglia of the brain. This destruction of brain cells causes progressive deterioration of both mental and physical abilities. The symptoms of the disease generally do not develop until...
PLEASE COMPUTER TYPED* OR VERY CLEAR HANDWRITING with details 1. Radioactive (14C) uridine (lots of it)...
PLEASE COMPUTER TYPED* OR VERY CLEAR HANDWRITING with
details
1. Radioactive (14C) uridine (lots of it) is added to a growing culture of bacteria for 10 seconds and then the drug rifamycin is added (rifamycin blocks the initiation of transcription, but not continued elongation of RNA polymerases that have already begun transcribing). At two-minute intervals, 1 ml samples are removed and placed on ice. The bacteria are lysed (broken open) and an enzyme is added that will chew up all...
What are the three functional groups that comprise a nucleotide? What do nucleotides have in common...
What are the three functional groups that comprise a nucleotide? What do nucleotides have in common with amino acids or simple sugars? When the structure of DNA was first elucidated, many biologists quickly saw how this structure explained the passage of information from one generation to another. How does the structure of DNA explain generation-to-generation flow of information? In other words, give a brief description of the structure of DNA and tell how this structure allows for replication. Which of...
Dystrophin is a protein that forms part of a vital protein complex that connects the cytoskeleton of a muscle fiber cell to the extracellular matrix. This connection strengthens and shapes the muscle fibers. Dystrophin is coded by the DMD gene. This is one of the longest human genes known, covering 2,300,000 base pairs (0.08% of the human genome) It is located in chromosome 21. The immature mRNA is 2,100,000 bases long and takes 16 hours to transcribe. It contains 79...
Review Questions BIOL 260: Chapters 8-10, 13, 19 1. Consider a mutation involving the deletion of either 1, 2, or 3 nucleotides in the DNA of a bacterium. Which of these mutations (ie., deletion of 1, 2, or 3 nucleotides) would likely have the LEAST impact on the organism? Why? Include in your answer a comparison with the other two options to justify your reasoning. Think carefully about the impact each mutation would have on the ultimate protein coded for...
TranslationOverview:The purpose of this activity is to help the students to understand how replication, transcription, and translation are connected. Students will use a sequence from a bacterial gene that confers resistance to antibiotics (carbapenems). They will be asked to apply the knowledge obtained in the class lecture to (1) find the promoter in the sequence, (2) determine the amino acid sequence of a fragment of the polypeptide, (3) "reverse translate" a fragment of the polypeptide, and (4) identify mutations in...
QUESTION 1 MC. Which of the following disease conditions might NOT be treatable by RNAI? a. arthritis b. Cancer caused by tumor suppressor gene mutation c. macular degeneration d. cancer caused by oncogen mutation S 5 QUESTION 2 MC. What is the molecular cause of male courtship behavior in fruit flies? a. Alternative splicing of the fruitless transcript b. RNA editing of the fruitless transcript C. Alternative sequence of the fruitless DNA d. Alternative 3' cleavage and polyadenylation of fruitless...
13. Why are ribonucleoside triphosphates the monomers required for RNA synthesis rather than ribonucleoside monophosphates? A. Only ribonucleoside triphosphates contain the sugar ribose. B. Ribonucleoside triphosphates have low potential energy, making the polymerization reaction endergonic. C. Ribonucleoside triphosphates have high potential energy, making the polymerization reaction exergonic. D. Ribonucleoside monophosphates cannot form complementary base pairs with the DNA template. E. Ribonucleoside triphosphates are not used, rather all use deoxyriboside triphosphates. 14. How is a mutation in a bacterial cell that...
number 5 please
Case Presentation Jordan is a healthy twenty-six year old male. He is an only child, son of Jessica age 45 and Ryan 43. Jordan is married and has no children. Eight years ago, Jordan's mother was diagnosed with Huntington's disease, a hereditary disease that destroys neurons in the basal ganglia of the brain. This destruction of brain cells causes progressive deterioration of both mental and physical abilities. The symptoms of the disease generally do not develop until...
PLEASE COMPUTER TYPED* OR VERY CLEAR HANDWRITING with
details
1. Radioactive (14C) uridine (lots of it) is added to a growing culture of bacteria for 10 seconds and then the drug rifamycin is added (rifamycin blocks the initiation of transcription, but not continued elongation of RNA polymerases that have already begun transcribing). At two-minute intervals, 1 ml samples are removed and placed on ice. The bacteria are lysed (broken open) and an enzyme is added that will chew up all...
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