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Think about histidine. What percentage of His side chains will be charged at physiological pH? The...

Think about histidine. What percentage of His side chains will be charged at physiological pH? The pKa of the histidine R group is 6.0; physiological pH is 7.4 Use the Henderson-Hasselbalch equation to help you answer this.

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Answer #1

Side chain of histidine is the imidazole part.

In acidic medium the most basic nitrogen is protonated as shown.

We know the formula PH+POH=14

PKa+PKb=14

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