Question

How the law of Laplace is related to ventricle structures of the heart? And how can Laplace law explain malfunction of ventricle contractions associated with dilated and hypertrophic cardiomyopathy hearts?

Plz type the answer

Answer 1

The law of Laplace describes the factors that determine left ventricular wall stress. Which is a major determinant of myocardial oxygen demand.

LV walll stress =(LV pressure* radius)/2* LV wall thickness

Left ventricular wall stress is the force acting against the myocardial cells.this is directly proportional to the ventricular pressure and radius.wall stress is indirectly proportional to two times the wall thickness.w

LV radius increase innvalvulin heart disease or cardiomyopathies causing systolic heart failure.

LV wall thickness increase is in chronic hypertension or aortic valve stenosis as a compensatory mechanisms to decrease wall stress there by decreasing oxygen demand becoz the stress distributed over a large mass.hypertrophic obstructive cardiomyopathies,similarly increase wall thickness, after myocardial indarinfar the wall thickness during remodeling which increases wall stress.