Question

A resting mast cell becomes activated due to response to a parasite. Which of the following scenarios is likely to occur?

a. The mast cell uses FceR1 to bind IgE that is parasite-specific and when the antibody is cross-linked histamine is released

b. The mast cell undergoes VDJ recombination and produces IgE antibody specific to the parasite

c. The mast cell binds directly to the parasite with its T-cell receptor and releases perforin

d. The mast cell makes IgE that binds to the parasite and induces parasite death

e. None of the above

Answer 1

Answer

Option B is correct i.e " The mast cell uses FceR1 to bind IgE that is parasite-specific and when the antibody is cross-linked histamine is released".

Explanation

Mast cells express receptors for IgE antibody i.e specific towards the allergen or parasite, in presence of parasite IgE antibody specific towards parasite binds to mast cells and causes the degranulation of mast cells and leads to the release of primary mediators like histamine that gives anti-allergic response to parasite.