Question

Mapping and identifying DNA modifications has proven to be quite challenging. Explain why this is. Think about how traditional DNA sequencing works and how it might be limited in detecting modifications.

Answer 1

DNA ( Deoxyribonucleic Acid) is the hereditary material found in all living organism. It contains the genetic information for the development and functioning of an organism. DNA mapping is variety of different methods that can be used for describe the position of gene. Genetic mapping or linkage mapping can be used to indicate the relative order of genes on a chromosome. DNA sequence, the precise ordering of the bases (A, T, G, C) from which DNA is composed. Base pairs form naturally only between A and T and between G and C so the base sequence of each single of DNA can be simply deduced from that of its partner strand. A chromasome contains number of genes and million of sequence containing in DNA strand so it's difficult to record the data is quite challenging and high cost. Now the mapping and sequencing is done by the help of computer but DNA can have mutation it may lead to disorder and disease a single strand change leads to this problem. A DNA contains millions of sequence and information is difficult to detect.