Question

1. Phenylketonuria occurs in 1/15,000 births in the US, 1/4500 births in Ireland and 1/120,000 births in Japan.
A. Calculate the number of carriers of PKU in each population.
B. How would these frequencies change if the mutation were found on the X chromosome?
C. How would these frequencies change if they were on the Y-chromosome?   

2. Go to https://en.wikipedia.org/wiki/Blood_type_distribution_by_country

And look at the table entitled “Ethnic distribution of ABO (without Rh) blood types” and find the entries for the following people:

1. Inuit (Alaska) and Inuit (Greenland).  
2. Jews (Germany) and Jews (Poland)
3. Romani (Hungary) and Indians (India)
4. Norwegians and Icelanders.

Part one: For each pair, calculate the genotypic frequencies of the A, B, and O alleles

Part two.   Each pair of these ethnic groups are historically related. Does this relatedness bear out in the blood types? What does this say about their migrations? You might want to look at other groups on the chart to answer this question.

Any help would be much appreciated!

Answer 1

ANSWER 1

​​​​​​Note :- In case of 2pq, these are the heterozygotes also called the carriers as they will be having a single copy of the mutant allele or affected allele. X-linked dominant and X-linked condition will not show presence of any carriers. Hence, the carriers frequency will be zero.