Question

A. Ketamine is an analgesic that has moved onto the street as a result of its hallucinogenic properties. How does ketamine interact with water molecules? (show structures)

B. Clinically, ketamine is typically stored prior to dilution for injection in a stock solution containing 100 mg/mL ketamine hydrochloride at pH 6.8. Given a molecular weight of 274.18 g/mol and a pKa of 7.5, determine the concentration of ketamine that is found in its hydrochloride form and the concentration in the free base form.

C. One of the consequences of ketamine overdoes is metabolic alkalosis. Explain how the respiratory rate of an overdose patient would change in response to this particular symptom.

D. Determine the value for ΔG°' for ketamine's acid dissociation reaction.

Thank you so much!

Answer 1