In the Williamson Ether Synthesis of Phenacetin from Acetaminophen, sodium methoxide in methanol and 100% ethanol...
In the Williamson Ether Synthesis of Phenacetin from Acetaminophen, sodium methoxide in methanol and 100% ethanol are added. This procedure initially states to use bromoethane, instead we used bromobutane. what is the new mechanism?
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In the Williamson Ether Synthesis of Phenacetin from
Acetaminophen, sodium methoxide in methanol and 100% ethanol...
In the synthesis of phenacetin from acetaminophen, an alcohol is converted to an ether. a. Is...
In the synthesis of phenacetin from acetaminophen, an alcohol is converted to an ether. a. Is the–OH in acetaminophen a nucleophile or electrophile? b. What is the function of the ethanol/NaOH? c. What is the function of the CH3 CH2I? d. Describe the mechanism of this reaction.Identify the nucleophile in each step. Use curved arrows to show bondsbreaking and forming. What is the leaving group? e. Would you get phenacetin by treating acetaminophen with sulfuric acid followed by ethanol? Give...
In a Williamson ether synthesis with sodium ethoxide and 1-bromobutane, with ethanol as the solvent, which...
In a Williamson ether synthesis with sodium ethoxide and 1-bromobutane, with ethanol as the solvent, which substances would be distilled and which substance would distill first?
Procedure: Measure and dispense 0.6 ml of a 4.4 M otion of sodium methoxide in methanol...
Procedure: Measure and dispense 0.6 ml of a 4.4 M otion of sodium methoxide in methanol and me of ethanol into a 5 mL reaction vial. Add 2.5 mmol of acetaminophen (40.378. Set up for reflux in the rume hood and bring reaction to reflux for 15 minutes (solvent is boiling and vapors are condensing condenser). After 15 minutes, directly through the top of the condenser tube, carefully add 0.3 ml of iemy iodide. Continue to reflux for another 45...
Draw the mechanism for the Williamson ether reaction using m-cresol and benzyl bromide (use sodium methoxide...
Draw the mechanism for the Williamson ether reaction using m-cresol and benzyl bromide (use sodium methoxide as the base).
A Williamson ether synthesis is shown below. 2-naphthol in the presence of sodium hydroxide undergoes a...
A Williamson ether synthesis is shown below. 2-naphthol in the
presence of sodium hydroxide undergoes a deprotonation to give the
alkoxide shown below. 1-Bromooctane is then added and undergoes a
nucleophilic substitution by SN2 mechanism. Add curved arrows to
demonstrate the SN2 substitution described.
A Williamson ether synthesis is shown below. 2-naphthol in the presence of sodium hydroxide undergoes a deprotonation to give the alkoxide shown below. 1-Bromooctane is then added and undergoes a nucleophilic substitution by SN2 mechanism. Add...
3. If sodium methoxide in methanol was used in place of potassium t butanol, your GC...
3. If sodium methoxide in methanol was used in place of potassium t butanol, your GC analysis would look much more like the 2-butanol/sulfuric acid reaction products. In addition, a new, non-alkene product would be present in the GC analysis from a competing, non-elimination mechanism. Explain why the alkene distribution would change, what the new product would be, and why this new product would form. 4. If 2-bromobutane was reacted with trimethylamine to produce sec-butyl trimethyl- ammonium bromide (see below),...
Help with question #4. The reaction can be taken from #1 . wILLIAMSON ETHER SYNTHESS: PREPARAT?ON...
Help with question #4. The reaction can be taken from #1
. wILLIAMSON ETHER SYNTHESS: PREPARAT?ON OF PHENACETN FROM ACETAMINOPHEN LA8 10 LAB 10 ? NAME DATE LAB SECTION Answer the following questions in the pre-lab section of your notebook. 1. Draw the mechanism for the reaction between phenacetin, potassium carbonate, and 2. List three limitations of the Williamson ether synthesis and explain how our choice of 3. What is the purpose of the rotary evaporator? What other technique that...
This is a williamson ether synthesis SN2 reaction. what are the complete mechanisms of this reaction,...
This is a williamson ether synthesis SN2 reaction. what are
the complete mechanisms of this reaction, with the intermediates
included?
MLNVILI SYNTHESIS OF 2-BUTOXYNAPHTHALENE OH 1. NaOH, ETOH 2. n-BuBr DISCUSSION: Nucleophilic substitution reaction is a frequently used method to convert one functional group into another. A nucleophile is mixed with an electrophile and the nucleophile replaces the leaving group to produce a new compound. In this experiment, a weak nucleophile (2-naphthol) is converted into a strong nucleophile. Then this...
please help me answer those three questions according to the oother pictures į CH, CH3 1....
please help me answer those three questions according to the
oother pictures
į CH, CH3 1. NaOMe in MeOH / EtOH, reflux 2. Ethyl lodide, reflux N bolo OH Acetaminophen phenacetini erot!) DAN Procedure: Measure and dispense 0.6 ml of a 4.4 M solution of sodium methoxide in methanol and im of ethanol into a 5 mL reaction vial. Add 215 mmol of acetaminophen (-0.378 8). Set up for reflux in the Tume hood and bring reaction to reflux for...
Hi! Can you please answer questions a and b for my organic lab report :) The...
Hi! Can you please answer questions a and b for my organic lab
report :) The pictures below the questions is my lab procedure.
Thank you
6. Analysis Questions: a) This lab utilized a new technique called reflux, and the use of a condenser tube while heating the reaction. What is the purpose of the condenser? Why not just heat the reaction in a closed vessel instead? b) A student misread the instructions and first refluxed the sodium methoxide in...
Procedure: Measure and dispense 0.6 ml of a 4.4 M otion of sodium methoxide in methanol and me of ethanol into a 5 mL reaction vial. Add 2.5 mmol of acetaminophen (40.378. Set up for reflux in the rume hood and bring reaction to reflux for 15 minutes (solvent is boiling and vapors are condensing condenser). After 15 minutes, directly through the top of the condenser tube, carefully add 0.3 ml of iemy iodide. Continue to reflux for another 45...
A Williamson ether synthesis is shown below. 2-naphthol in the
presence of sodium hydroxide undergoes a deprotonation to give the
alkoxide shown below. 1-Bromooctane is then added and undergoes a
nucleophilic substitution by SN2 mechanism. Add curved arrows to
demonstrate the SN2 substitution described.
A Williamson ether synthesis is shown below. 2-naphthol in the presence of sodium hydroxide undergoes a deprotonation to give the alkoxide shown below. 1-Bromooctane is then added and undergoes a nucleophilic substitution by SN2 mechanism. Add...
3. If sodium methoxide in methanol was used in place of potassium t butanol, your GC analysis would look much more like the 2-butanol/sulfuric acid reaction products. In addition, a new, non-alkene product would be present in the GC analysis from a competing, non-elimination mechanism. Explain why the alkene distribution would change, what the new product would be, and why this new product would form. 4. If 2-bromobutane was reacted with trimethylamine to produce sec-butyl trimethyl- ammonium bromide (see below),...
Help with question #4. The reaction can be taken from #1
. wILLIAMSON ETHER SYNTHESS: PREPARAT?ON OF PHENACETN FROM ACETAMINOPHEN LA8 10 LAB 10 ? NAME DATE LAB SECTION Answer the following questions in the pre-lab section of your notebook. 1. Draw the mechanism for the reaction between phenacetin, potassium carbonate, and 2. List three limitations of the Williamson ether synthesis and explain how our choice of 3. What is the purpose of the rotary evaporator? What other technique that...
This is a williamson ether synthesis SN2 reaction. what are
the complete mechanisms of this reaction, with the intermediates
included?
MLNVILI SYNTHESIS OF 2-BUTOXYNAPHTHALENE OH 1. NaOH, ETOH 2. n-BuBr DISCUSSION: Nucleophilic substitution reaction is a frequently used method to convert one functional group into another. A nucleophile is mixed with an electrophile and the nucleophile replaces the leaving group to produce a new compound. In this experiment, a weak nucleophile (2-naphthol) is converted into a strong nucleophile. Then this...
please help me answer those three questions according to the
oother pictures
į CH, CH3 1. NaOMe in MeOH / EtOH, reflux 2. Ethyl lodide, reflux N bolo OH Acetaminophen phenacetini erot!) DAN Procedure: Measure and dispense 0.6 ml of a 4.4 M solution of sodium methoxide in methanol and im of ethanol into a 5 mL reaction vial. Add 215 mmol of acetaminophen (-0.378 8). Set up for reflux in the Tume hood and bring reaction to reflux for...
Hi! Can you please answer questions a and b for my organic lab
report :) The pictures below the questions is my lab procedure.
Thank you
6. Analysis Questions: a) This lab utilized a new technique called reflux, and the use of a condenser tube while heating the reaction. What is the purpose of the condenser? Why not just heat the reaction in a closed vessel instead? b) A student misread the instructions and first refluxed the sodium methoxide in...
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