Question

Select the two statements that correctly describe the catalytic mechanism of lysozyme.

• Formation of a C−O bond by the carboxylate of Asp52.

• Asp52 is surrounded by nonpolar residues that stabilize its unprotonated form.

• Formation of a resonance‑stabilized oxonium ion.

• Water acts as a proton donor prior to a nucleophilic attack by Asp52.

• The hexose ring at the site of cleavage undergoes a conformational change from a chair to a boat.

Answer 1

Answers to check:

Formation of a C−O bond by the carboxylate of Asp52.

Formation of a resonance‑stabilized oxonium ion.

Asp-52 helps to stabilizes the oxonium ion, surrounded by polar groups, acts as a nucleophilic catalysis and forms a covalent bond with NAM.

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