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How can bacteria resist killing from cationic antimicrobial peptides (CAMPs)? Choose all that apply. a. Use...

How can bacteria resist killing from cationic antimicrobial peptides (CAMPs)? Choose all that apply. a. Use a protease to cleave and inactivate the CAMP b. Add more negatively charged molecules to the outer membrane c. Increase the permeability of the outer membrane d. Mask negatively charged molecules on the outer membrane

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Answer #1

Cationic antimicrobial peptides-

  • damage bacterial plasma membrane
  • Electostatic interaction with membrane- the formation of ionic pores and/or transient gaps thereby altering membrane permiabilty.
  • Eg.- Cathelicidin , Defensins , Histatin.

Ans. - (a) use proteases to cleave and inactivate CAMPs

(Eg.-the protease OmpT contributes CAMP resistant in E.coli.Stumpe et al.)

Ans.(d) mask negative charge. Bacteria establish biofilms on outer surface.capsule production.

  • Bacteria adds positive charge to the outer membrane to repel cationic peptides.
  • Permeability of membrane is reduced.
  • Efflux pumps moves toxic compounds out of cells. Play important role in resistant
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