Question

FOR THE CYCLIC REACTION ABOVE OF GOLD FOR EACH STEP CAN YOU GIVE METAL OXIDATION AND ELECTRON COUNT AND EXPLAIN A LITTLE WHATS HAPPENING THANK YOU

Scheme 1. Angle-Strain-Controlled Distinct Regioselectivities of Gold-Catalyzed Cyclizations Me R2 LAu() Reported2b, 2 R1R3 This work Ph3PAuNTf2 Scheme 2. Proposed Mechanism of the Cyclizations" Au TS1-2 (13.8) LAu* TS2-3 (0.6) LAut (0.0) (-29.7, after a catalytic cycle) R = Ph, L PPh3 LAu TS5-1 (6.2) 16.2 2n LAut OH TS4-5 (8.9) (-21.3)

Answer 1

Nazarow Reaction AICI, The Nazarow Cyclization allows the synthesis of cyclopentenones from divinyl ketoner Mechanism of the Nazarov Cyclizstion The reaction s catalyzed by strong Lewis or Branstedt acids, and one or more equivalents of the Lewis acid are normally necessary- The regioselectivity of the cycízetion is quite low if the side chains have 쓰 similar degree of substitution. Nazarov reactions with more highly substituted subatrates generate the product having the double bond with the highest degree of subatitution: AICI, Electron-donating and-withdrewing substituents can polarize the conjugsted systerm in the Nazarov Reaction, which facilitstes the cyclization and gives better regioselectivity: acle EDO

99% OSOL) S. E. Danmark, T.K. Jenas, J Am Cho Soc, 1982, 104 2642 r.t, 5 min 1, 40 min craton Ph Ph LUMOOH Ph HOMO aymmtric induetian coul b achievdhLawia asid werbantl the direstion of the