Propose a pathway(s) to explain how the ectoderm and the notochord block the ability of the endod...

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Propose a pathway(s) to explain how the ectoderm and the notochord block the ability of the endod...

Propose a pathway(s) to explain how the ectoderm and the notochord block the ability of the endoderm to express liver-specific genes during liver formation. (please include citaion) Please type out the answer please

science Anatomy-And-Physiology

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Answer 1

Answer #1

There is positive and negative signaling in formation of hepatic endoderm.

1. Mesoderm induces liver bud formation

2. Dorsal endoderm: hepatogenesis is blocked

3. Hepatic region of gut endoderm epressing a-fetal protein and albumin

How does it happen?

a. The ectoderm and the notochord block the ability of the endoderm to express the liver-specific genes.

b. The cardiogenic mesoderm, through the FGFs promote liver specific gene transcription

They do this by blocking the inhibitory factors induced by surrounding tissues.

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Answer 2

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Propose a pathway(s) to explain how the ectoderm and the notochord block the ability of the endod...

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