Please show how you would synthesize a terminal ALKYNE to this fluorescein dye. Terminal alkyne s...

Question

Question

Please show how you would synthesize a terminal ALKYNE to this fluorescein dye.

Terminal alkyne should be added to the bottom aromatic (with the COOH group)

you can use any reagent possible

COOH

Answer 1

Answer #1

We can add terminal alkyne through Friedel-Craft alkylation/acylation as shown below:

HO COOH Fa Br 3 HO COOH CHCNHCH.CCH

Answer 2

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