Question

12. Suicide substrates. Show why selegline behaves as a kcat inhibitor ("suicide substrate") specific for monoamine oxidase. Hy seleglne What is the role of the flavin cofactor that is associated with MAO in promoting amine oxidation? 13. Affinity labels. Design an affinity label specific for a serine endo-protease that specifically cleaves proteins at the C-terminal side of the bulky aliphatic residues Ile or Leu

Answer 1

Function MAD ' FA Ph 내2 3 Stable Conplexfem Depondent MAO

R. FAD R. R. fADH2. 아 el-echen at awm.he- substr.G dives tow m Cosachov fAD